Individuals at higher threat of acetaminophen and codeine phosphate tablets abuse include things like All those which has a history of prolonged usage of any opioid, including goods containing codeine, those using a background of drug or Liquor abuse, or individuals that use acetaminophen and codeine phosphate tablets together with other abused medication.
If an opioid analgesic is initiated inside a individual now getting a benzodiazepine or other CNS depressant, prescribe a decrease First dose of the opioid analgesic, and titrate determined by clinical response. Advise individuals and caregivers of the likely interaction, educate them about the signs and symptoms of respiratory despair (which includes sedation).
The concomitant utilization of acetaminophen and codeine phosphate tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may cause a rise in codeine plasma concentrations along with a lessen in active metabolite morphine plasma concentration which could result in an analgesic efficacy reduction or indicators of opioid withdrawal.
Habit, Abuse, and Misuse As the usage of acetaminophen and codeine phosphate tablets expose individuals and also other buyers to the pitfalls of opioid addiction, abuse, and misuse, which can result in overdose and Demise, evaluate Each individual individual’s possibility previous to prescribing and reassess all patients regularly for the development of these behaviors and circumstances (see WARNINGS).
Speak to your Health care service provider about naloxone, a medicine for your crisis treatment of an opioid overdose.
Opioid use increases the risk of CSA in a very dose-dependent fashion. In clients who present with CSA, look at decreasing the opioid dosage working with very best tactics for opioid taper (see DOSAGE AND ADMINISTRATION).
If 1 isn't offered, you can eliminate Acetaminophen and Codeine Phosphate Tablets, USP by mixing the item with Dust, more info cat litter, or coffee grounds; putting the combination in the sealed click here plastic bag, and throwing the bag in your trash.
Discontinuation/reduction ideas really check here should be individualized and get into consideration various aspects such as here type of soreness, dose and length of therapy, and client particular Actual physical and psychological characteristics; patients really should obtain ongoing treatment and adhere to-up that addresses arranged and realistic aims.
Right before utilizing this medication, Gals of childbearing age ought to speak with their physician(s) in regards to the risks and Rewards. Notify your physician If you're pregnant or if you intend to be pregnant. For the duration of pregnancy, this medication should be employed only when Plainly wanted. It may marginally enhance the risk of beginning defects if applied over the initial two months of pregnancy. Also, making use of it for a very long time or in high doses near the anticipated shipping day may perhaps harm the unborn child.
Acetaminophen and codeine phosphate tablets are contraindicated for postoperative management in pediatric individuals younger than 18 many years of age next tonsillectomy and/or adenoidectomy (see CONTRAINDICATIONS).
In some individuals, codeine breaks down promptly in the liver and reaches better than normal amounts in the human body. This can cause dangerously sluggish breathing and should induce Loss of life, particularly in a child.
pregnant or intending to grow to be Expecting. Utilization of acetaminophen and codeine phosphate tablets for an prolonged length of time throughout pregnancy could potentially cause withdrawal signs or symptoms inside your new child infant which could be lifetime-threatening if not identified and treated.
Recommend patients and caregivers that when medicines are not essential, they must be disposed of promptly. Inform sufferers that medication acquire-again choices are the preferred technique to properly dispose of most kinds of unneeded medicines.
Other discomfort relievers (which include naproxen, ibuprofen) could also be prescribed using this type of medication. Ask your doctor or pharmacist about using this check here product safely with other medicine.